Grant: Operating Grant
Université de Montréal
$636,800.00
Study of the pathogenesis and reversibility of airway damage and repair (remodeling) during chronic mucosal immune response to environmental allergens in a large animal model of asthma.
FY 2009-10
Summary
In human asthma, repeated exposure to environmental allergens leads to persistent inflammation and damage (remodeling)
of the lungs, and a progressive loss of airway function. Our proposed studies aim to determine 1) if the lesions present in the
lung tissue of asthmatic individuals are reversible by decreasing the level of allergen exposure or by the administration of
corticosteroids and antileukotrienes, two common therapeutics for this condition, and 2) if so, identify the cells and the
mediators responsible for these changes. These results will provide insight to the relationship between inflammation,
remodeling and airway function and may lead to the discovery of novel anti-remodeling therapy. These studies are
conducted in equine heaves, a natural disease of horses that shares many similarities with human asthma.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
188748
Name
Lavoie Jean-Pierre
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
Study of the pathogenesis and reversibility of airway damage and repair (remodeling) during chronic mucosal immune response to environmental allergens in a large animal model of asthma.
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$636,800
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Airway Smooth Muscle Remodeling; Equine Heaves; Expression Arrays (Ssh; Extracellular Matrix; Laser Microdissection; Lung Function; Microarrays)
Abstract
In human asthma, repeated exposure to environmental allergens leads to persistent inflammation and damage (remodeling)
of the lungs, and a progressive loss of airway function. Our proposed studies aim to determine 1) if the lesions present in the
lung tissue of asthmatic individuals are reversible by decreasing the level of allergen exposure or by the administration of
corticosteroids and antileukotrienes, two common therapeutics for this condition, and 2) if so, identify the cells and the
mediators responsible for these changes. These results will provide insight to the relationship between inflammation,
remodeling and airway function and may lead to the discovery of novel anti-remodeling therapy. These studies are
conducted in equine heaves, a natural disease of horses that shares many similarities with human asthma.
Competitiondate
200909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Lavoie, Jean-Pierre
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $636,800~ $0~
