Grant: Research Tools and Instruments - Category 1 (<$150,000)

A Fluorescence Activated Cell Sorter (FACS) is a machine capable of separating specific individual cells from other cells based on the proteins that they express on their surface. The cell surface proteins used to distinguish these cells are tagged with a fluorescent dye prior to the separation, hence the name. These machines can sort 10,000 cells per second and the source of the cells can be tissues or blood of animals or cells that have been cultured in a dish. The cells that have been separated based on their specific features can then be grown and/or analysed in isolation to determine their specific features or functions, without the other types of cells interfering in the analysis. Many researchers from varying disciplines require this capability to perform cutting edge research, including scientists, engineers, pharmacists and optometrists. Their projects span the spectrum of biological investigation, from the development of new drug delivery techniques, to developing better drugs, improving outcomes of eye disease, diabetes and cancer, producing cleaner drinking water, as well as improving the health of aquaculture fish in order to protect wild fish and increase food production. In all cases the cells studied will provide critical information important for developing new drugs and techniques that will maintain and promote the health and well being of Canadians as well as the animals in their environment.