Grant: Operating Grant
University of Calgary
$665,010.00
The mechanical causes of osteoarthritis
FY 2012-13
Summary
Not all individuals who sustain severe knee joint injuries go on to develop osteoarthritis. Our previous work has shown that changes in gait patterns and inflammation are known to occur immediately after a ligament or meniscal injury for all individuals. We propose that such individuals who do develop OA have on-going biomechanical changes in their gait patterns following injury. Furthermore, these changes may inhibit repair or replacement of key damaged knee structures. It is essential to detect these biomechanical changes early to prevent the initiation and progression of OA in these individuals. We have been able to develop a sensitive and innovative technology for identifying minute changes in gait. We are now well positioned to use this technology on our well established animal model of OA development to study the early detection of osteoarthritis.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
265613
Name
Shrive Nigel G
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Biomedical Engineering
Projecttitle
The mechanical causes of osteoarthritis
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$665,010
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Joint Injury; Joint Kinematics; Joint Loads; Motion Analysis; Osteoarthritis; Robot; Spatial Linkage
Abstract
Not all individuals who sustain severe knee joint injuries go on to develop osteoarthritis. Our previous work has shown that changes in gait patterns and inflammation are known to occur immediately after a ligament or meniscal injury for all individuals. We propose that such individuals who do develop OA have on-going biomechanical changes in their gait patterns following injury. Furthermore, these changes may inhibit repair or replacement of key damaged knee structures. It is essential to detect these biomechanical changes early to prevent the initiation and progression of OA in these individuals. We have been able to develop a sensitive and innovative technology for identifying minute changes in gait. We are now well positioned to use this technology on our well established animal model of OA development to study the early detection of osteoarthritis.
Competitiondate
201209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Shrive, Nigel G
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $665,010~ $0~
