Grant: Operating Grant
Université de Sherbrooke
$669,535.00
Genetic regulation and molecular mechanisms of TPP riboswitches. Régulation génétique et mécanismes moléculaires des riborégulateurs TPP.
FY 2011-12
Summary
Riboswitches are structured RNA elements typically found in the 5' untranslated regions (5'-UTR) of mRNAs, where they regulate gene expression by binding to small metabolites. A major goal of our research is to unravel the molecular mechanisms by which the TPP riboswitches harness the binding of ligands to selectively control gene expression. An understanding of the interactions between riboswitches and their metabolite ligands should provide insights into the ability of RNA to act as a genetic switch. This knowledge might empower future efforts to design novel general antimicrobial drug development approaches for generating analogs of riboswitch ligands, disrupt regulation of key metabolic pathways, and thus be selectively toxic to bacteria that carry these RNAs.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
239248
Name
Lafontaine Daniel
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Genetic regulation and molecular mechanisms of TPP riboswitches. Régulation génétique et mécanismes moléculaires des riborégulateurs TPP.
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$669,535
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Antibacterial Compounds; Biochemistry Of Nucleic Acids; Folding Mechanisms; Gene Expression Regulation; Riboswitches; Rna Folding And Dynamics; Rna-Ligand Interactions; Single-Molecule Techniques; Thiamin Pyrophosphate (Tpp)
Abstract
Riboswitches are structured RNA elements typically found in the 5' untranslated regions (5'-UTR) of mRNAs, where they regulate gene expression by binding to small metabolites. A major goal of our research is to unravel the molecular mechanisms by which the TPP riboswitches harness the binding of ligands to selectively control gene expression. An understanding of the interactions between riboswitches and their metabolite ligands should provide insights into the ability of RNA to act as a genetic switch. This knowledge might empower future efforts to design novel general antimicrobial drug development approaches for generating analogs of riboswitch ligands, disrupt regulation of key metabolic pathways, and thus be selectively toxic to bacteria that carry these RNAs.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Lafontaine, Daniel
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $669,535~ $0~
