Grant: Operating Grant
University of British Columbia
$100,000.00
Understanding the immunological basis for early-life infections in preterm infants
FY 2010-11
Summary
One of the body's most vital functions is its ability to fight off infections. Immune cells constitute special and well tuned machineries whose goal is to recognize microbial invaders and produce a protective response for keeping us healthy. Adults are able to fend off infections much better than are infants. However, the reasons for the greater vulnerability of infants to infections and the development of immune defences early in life remains poorly understood. The goal of our research is to examine the way the human immune cells work early in life and to gain insights on why premature newborns are so susceptible to infections. Ultimately, we hope that a better understanding of factors responsible for the reduced ability to fight off serious infections will help researchers and doctors develop better treatments to prevent the dreadful consequences of infections in vulnerable newborns.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
223210
Name
Lavoie Pascal
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Clinical Investigation - A: Reproduction, Maternal, Child and Youth Health
Projecttitle
Understanding the immunological basis for early-life infections in preterm infants
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Innate Immunity; Longitudinal Human Study; Molecular Mechanisms; Premature Infants; Toll-Like Receptor; Vulnerability To Infections
Abstract
One of the body's most vital functions is its ability to fight off infections. Immune cells constitute special and well tuned machineries whose goal is to recognize microbial invaders and produce a protective response for keeping us healthy. Adults are able to fend off infections much better than are infants. However, the reasons for the greater vulnerability of infants to infections and the development of immune defences early in life remains poorly understood. The goal of our research is to examine the way the human immune cells work early in life and to gain insights on why premature newborns are so susceptible to infections. Ultimately, we hope that a better understanding of factors responsible for the reduced ability to fight off serious infections will help researchers and doctors develop better treatments to prevent the dreadful consequences of infections in vulnerable newborns.
Competitiondate
201010
Approvedterm2
1 yr 0 mth
Pinamesdelim
Lavoie, Pascal
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
