Grant: Operating Grant
University of Ottawa
$587,635.00
The Lysine Methylome
FY 2009-10
Summary
Thousands of biochemical reactions take place simultaneously in each cell. Among those, chemical alterations of proteins, the building block of any living organism, are of pivotal importance in eliciting a given biological response. Correlatively, if these chemical reactions cannot take place properly, diseases such as cancer and Alzheimer arise. Our laboratories seek to identify, locate and precise the role of a specific modification named lysine methylation, which is recognized as a key modification during many pathology's. Our discoveries will 1) provide the biochemical bases underlying the role of lysine methylation in a biological process 2) further our understanding on the linkages between this chemical modification and various forms of cancer and 3) provide new and innovative therapeutic strategies to treat these diseases.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
189299
Name
Couture Jean-François
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genomics: Systems and computational biology
Projecttitle
The Lysine Methylome
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$587,635
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cancer; Methylation; Peptide Fingerprinting; Proteome-Scale Analysis; Proteomics; Set Domain Proteins
Abstract
Thousands of biochemical reactions take place simultaneously in each cell. Among those, chemical alterations of proteins, the building block of any living organism, are of pivotal importance in eliciting a given biological response. Correlatively, if these chemical reactions cannot take place properly, diseases such as cancer and Alzheimer arise. Our laboratories seek to identify, locate and precise the role of a specific modification named lysine methylation, which is recognized as a key modification during many pathology's. Our discoveries will 1) provide the biochemical bases underlying the role of lysine methylation in a biological process 2) further our understanding on the linkages between this chemical modification and various forms of cancer and 3) provide new and innovative therapeutic strategies to treat these diseases.
Competitiondate
200909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Couture, Jean-François; Figeys, Daniel
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $587,635~ $0~
