Grant: Travel Awards - Institute Community Support
Centre hospitalier de l'Université de Montréal (CHUM)
$1,500.00
Vitamin A transporter RBP4 concentrations are specifically altered in obese and in type 2 diabetes patients blood RBP4, le transporteur de Vitamine A sérique, augmente spécifiquement avec l'obésité et le diabète de type 2
FY 2015-16
Summary
Hepatic RBP4 (retinol binding protein) is the circulating vitamin A (ROL) carrier. The transthyretine (TTR) enhances ROLRBP4
complex molecular weight, to prevent early kidney filtration, and allow ROL to tissues. The RBP4 is also an adipokine,
secreted by fat tissues. Exogenous administration of RBP4 induces insulin resistance (IR) in animals. Circulating RBP4 were
found elevated in type 2 diabetes (T2DM) but their raise in obesity alone or in obesity and diabetes, together with their
relation with TTR in these diseases are subjects of some controversy. Here we show serum levels of RBP4 are increased in
obesity and diabetes and correlates with traditional biochemical and biometrical indicators of metabolic syndrome and
diabetes.
Department
Program
Travel Awards - Institute Community Support
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
337293
Name
Sima Aurelia
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Institute of Nutrition, Metabolism and Diabetes
Projecttitle
Vitamin A transporter RBP4 concentrations are specifically altered in obese and in type 2 diabetes patients blood RBP4, le transporteur de Vitamine A sérique, augmente spécifiquement avec l'obésité et le diabète de type 2
Programtype2
Undefined
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Bourses De Voyage D'Aci; Insulin Resistance; Metabolic Syndrome; Obesity; Rbp4; Ttr; Type 2 Diabetes; Vitamin A Metabolism
Abstract
Hepatic RBP4 (retinol binding protein) is the circulating vitamin A (ROL) carrier. The transthyretine (TTR) enhances ROLRBP4
complex molecular weight, to prevent early kidney filtration, and allow ROL to tissues. The RBP4 is also an adipokine,
secreted by fat tissues. Exogenous administration of RBP4 induces insulin resistance (IR) in animals. Circulating RBP4 were
found elevated in type 2 diabetes (T2DM) but their raise in obesity alone or in obesity and diabetes, together with their
relation with TTR in these diseases are subjects of some controversy. Here we show serum levels of RBP4 are increased in
obesity and diabetes and correlates with traditional biochemical and biometrical indicators of metabolic syndrome and
diabetes.
Competitiondate
201510
Approvedterm2
1 yr 0 mth
Pinamesdelim
Sima, Aurelia
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $1,500~ $0~
