Grant: Project Grant
Centre for Addiction and Mental Health (Toronto)
$465,885.00
Transdiagnostic multi-scale neural signatures of endocannabinoid function and their role in cognitive and psychological functioning in psychiatric conditions
FY 2024-25
Summary
Fatty Acid Amide Hydrolase is the enzyme that regulates brain levels of the endocannabinoid anandamide and it is a uniquely interesting target for the development of treatments for psychiatric conditions. The present brain imaging project will clarify the role of this enzyme in cognitive and psychological functions such as impulsivity, reward and negative mood in a large sample of people with different psychiatric conditions. Results of this study may help us better understand which symptoms could be alleviated by targeting endocannabinoids, which would be an advance in the therapeutics for psychiatric conditions and a public health achievement more generally.
Department
Program
Project Grant
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
523240
Name
Zhukovsky Peter
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Behavioural Sciences - B: Clinical Behavioural Sciences
Projecttitle
Transdiagnostic multi-scale neural signatures of endocannabinoid function and their role in cognitive and psychological functioning in psychiatric conditions
Programtype2
Operating Grants
Orgnameinp2
Centre for Addiction and Mental Health (Toronto)
Cihramount2
$465,885
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Endocannabinoid; Mri; Multivariate Regression; Pet; Psychiatry
Abstract
Fatty Acid Amide Hydrolase is the enzyme that regulates brain levels of the endocannabinoid anandamide and it is a uniquely interesting target for the development of treatments for psychiatric conditions. The present brain imaging project will clarify the role of this enzyme in cognitive and psychological functions such as impulsivity, reward and negative mood in a large sample of people with different psychiatric conditions. Results of this study may help us better understand which symptoms could be alleviated by targeting endocannabinoids, which would be an advance in the therapeutics for psychiatric conditions and a public health achievement more generally.
Competitiondate
202503
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Zhukovsky, Peter; Boileau, Isabelle
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $465,885~ $0~
