Grant: Project Grant
Centre for Addiction and Mental Health (Toronto)
$1,059,524.00
Investigating endocannabinoid signaling in relapse to alcohol drinking: neuroimaging studies of Fatty Acid Amide Hydrolase in alcohol use disorder
FY 2017-18
Summary
Fatty Acid Amide Hydrolase (FAAH) is the enzyme that regulates brain levels of the endocannabinoid, anadamide, and it is a uniquely interesting target for the development of therapeutics for alcohol use disorder. The present brain imaging project will determine whether low levels of this enzyme during early abstinence from alcohol is associated with relapse and whether enzyme levels remain low or normalize during protracted abstinence. Results of this study may help develop treatment responsive biomarkers for alcohol use disorder which is a major public health priority.
Department
Program
Project Grant
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
369703
Name
Boileau Isabelle
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Clinical
Prcname2
Behavioural Sciences - B: Clinical Behavioural Sciences
Projecttitle
Investigating endocannabinoid signaling in relapse to alcohol drinking: neuroimaging studies of Fatty Acid Amide Hydrolase in alcohol use disorder
Programtype2
Operating Grants
Orgnameinp2
Centre for Addiction and Mental Health (Toronto)
Cihramount2
$1,059,524
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Alcohol Use Disorder; Biomarker; Endocannabinoid; Fatty Acid Amide Hydrolase; Relapse
Abstract
Fatty Acid Amide Hydrolase (FAAH) is the enzyme that regulates brain levels of the endocannabinoid, anadamide, and it is a uniquely interesting target for the development of therapeutics for alcohol use disorder. The present brain imaging project will determine whether low levels of this enzyme during early abstinence from alcohol is associated with relapse and whether enzyme levels remain low or normalize during protracted abstinence. Results of this study may help develop treatment responsive biomarkers for alcohol use disorder which is a major public health priority.
Competitiondate
201709
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Boileau, Isabelle
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $1,059,524~ $0~
