Grant: Project Grant
University of Ottawa
$1,040,400.00
Deciphering the Role of the histone chaperone SRCAP in Neurodevelopmental Disorders: Implications for Neurodevelopment and Gene Regulation
FY 2025-26
Summary
Neurodevelopmental disorders (NDDs) are complex conditions with a strong genetic component involving over 3,000 genes. Among these, the SRCAP gene stands out due to its significant role in brain development. Mutations in SRCAP are linked to numerous NDDs, including autism, ADHD and bipolar disorder.
SRCAP's role in the brain has never been addressed. SRCAP acts mainly by depositing a protein called H2A.Z within our DNA, which influences how certain genes are turned on or off during brain development.
This project is set to unravel the mechanisms through which disruptions in SRCAP function lead to issues in brain development, contributing to NDDs. We will use a new animal model to understand how the loss of SRCAP influences the placement of H2A.Z in brain cells and its impact on gene activity during brain development. We will use use cells from patients with SRCAP mutations to better understand how disruption in SRCAO causes disease.
Our research will produce data that will contribute to our understanding of brain development and open new possibilities for people affected by NDDs.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
531916
Name
stefanelli gilda
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Deciphering the Role of the histone chaperone SRCAP in Neurodevelopmental Disorders: Implications for Neurodevelopment and Gene Regulation
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$1,040,400
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Epigenetics; Gene Expression; Histone Chaperone; Histone Variant; Neurodevelopment
Abstract
Neurodevelopmental disorders (NDDs) are complex conditions with a strong genetic component involving over 3,000 genes. Among these, the SRCAP gene stands out due to its significant role in brain development. Mutations in SRCAP are linked to numerous NDDs, including autism, ADHD and bipolar disorder.
SRCAP's role in the brain has never been addressed. SRCAP acts mainly by depositing a protein called H2A.Z within our DNA, which influences how certain genes are turned on or off during brain development.
This project is set to unravel the mechanisms through which disruptions in SRCAP function lead to issues in brain development, contributing to NDDs. We will use a new animal model to understand how the loss of SRCAP influences the placement of H2A.Z in brain cells and its impact on gene activity during brain development. We will use use cells from patients with SRCAP mutations to better understand how disruption in SRCAO causes disease.
Our research will produce data that will contribute to our understanding of brain development and open new possibilities for people affected by NDDs.
Competitiondate
202509
Approvedterm2
5 yrs 0 mth
Pinamesdelim
stefanelli, gilda
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,040,400~ $0~
