Grant: Operating Grant
Research Institute of the McGill University Health Centre
$709,716.00
Functional characterization and fine mapping of a type 2 diabetes risk locus near IRS1.
FY 2009-10
Summary
Adult-onset diabetes frequently occurs in family members as a result of inherited changes in the sequence of their genes. We have discovered a number of changes in DNA can make people more prone to developing diabetes. In the current project, we will study the physiologic effects of one of these these DNA changes to determine how it increases a person's risk of developing diabetes. In particular, we will determine how a genetic change on human chromosome 2 affects insulin's ability to alter cellular metabolism.
Department
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
191087
Name
Sladek Robert G
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
Functional characterization and fine mapping of a type 2 diabetes risk locus near IRS1.
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$709,716
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Chromatin Structure; Diabetes Genetics; Diabetes Pathogenesis; Functional Genomics; Gene Expression; Transcription Factors
Abstract
Adult-onset diabetes frequently occurs in family members as a result of inherited changes in the sequence of their genes. We have discovered a number of changes in DNA can make people more prone to developing diabetes. In the current project, we will study the physiologic effects of one of these these DNA changes to determine how it increases a person's risk of developing diabetes. In particular, we will determine how a genetic change on human chromosome 2 affects insulin's ability to alter cellular metabolism.
Competitiondate
200909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sladek, Robert G
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $709,716~ $0~
