Grant: Project Grant
Research Institute of the McGill University Health Centre
$852,975.00
Identification and characterization of a novel polysaccharide virulence factor of Aspergillus fumigatus
FY 2017-18
Summary
Aspergillus fumigatus is a mold that causes severe, often fatal pneumonia. This infection is common in patients with abnormal immune systems, such as those receiving chemotherapy or following organ or bone marrow transplantation. We have identified a sugar molecule that is produced by Aspergillus which is required for this fungus to cause pneumonia. We will determine how this sugar molecule helps the fungus cause disease, and develop new therapies that target this process in order to help improve outcomes in Aspergillus pneumonia.
Department
Program
Project Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
369625
Name
Sheppard Donald C
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Microbiology & Infectious Diseases
Projecttitle
Identification and characterization of a novel polysaccharide virulence factor of Aspergillus fumigatus
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$852,975
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Aspergillus; Biosynthesis; Host Pathogen Interactions; Polysaccharides; Therapeutics; Virulence
Abstract
Aspergillus fumigatus is a mold that causes severe, often fatal pneumonia. This infection is common in patients with abnormal immune systems, such as those receiving chemotherapy or following organ or bone marrow transplantation. We have identified a sugar molecule that is produced by Aspergillus which is required for this fungus to cause pneumonia. We will determine how this sugar molecule helps the fungus cause disease, and develop new therapies that target this process in order to help improve outcomes in Aspergillus pneumonia.
Competitiondate
201709
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sheppard, Donald C
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $852,975~ $0~
