Grant: Emerging Team Grant: Regenerative Medicine and Nanomedicine - LOI

One of the major challenges of replacing or regenerating tissues using tissue engineering approaches is the ability to obtain a functional blood supply following implantation of the construct or cells into the body. This team submission will be focused on the biology of regenerating blood vessels and specifically endothelial cells (EC), the cells which line the internal surfaces of all blood vessels. Studies will examine the influence of EC interactions with other cell types, as well as the effects of blood flow. The new knowledge obtained on EC function during remodeling will be used to design novel therapies with a view to achieving improved/accelerated vascularization.