Grant: Project Grant
University of Ottawa
$527,505.00
Functional proteomics of lysine and arginine methylation signalling in health and disease
FY 2015-16
Summary
Thousands of biochemical reactions take place simultaneously in each cell. Among those, chemical alterations of proteins, the building block of any living organism, are of pivotal importance in eliciting a given biological response. Correlatively, if these chemical reactions cannot take place properly, diseases such as cancers and Alzheimer arise. Our laboratories seek to identify, locate and precise the role of a specific modification named lysine methylation. Recognized as a key modifications during many pathologies, our discoveries will 1) provide the biochemical bases underlying the role of lysine methylation in a biological process 2) further our understanding on the linkages between this chemical modification and various forms of cancer and 3) provide new and innovative therapeutic strategies to treat these diseases.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
343431
Name
Couture Jean-François
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Functional proteomics of lysine and arginine methylation signalling in health and disease
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$527,505
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Arginine Methylation; Lysine Methylation; Post-Translational Modifications; Proteomics; Set Domain Methyltransferases; Systems Biology
Abstract
Thousands of biochemical reactions take place simultaneously in each cell. Among those, chemical alterations of proteins, the building block of any living organism, are of pivotal importance in eliciting a given biological response. Correlatively, if these chemical reactions cannot take place properly, diseases such as cancers and Alzheimer arise. Our laboratories seek to identify, locate and precise the role of a specific modification named lysine methylation. Recognized as a key modifications during many pathologies, our discoveries will 1) provide the biochemical bases underlying the role of lysine methylation in a biological process 2) further our understanding on the linkages between this chemical modification and various forms of cancer and 3) provide new and innovative therapeutic strategies to treat these diseases.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Couture, Jean-François; Figeys, Daniel
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $527,505~ $0~
