Grant: Collaborative Health Research Projects (NSERC partnered)
University of British Columbia
$453,152.00
Development of an automated end-to-end next generation sequencing assay to detect all classes of genetic variant in a single diagnostic test
FY 2015-16
Summary
Each year more than 190,000 Canadians are diagnosed with cancer and about 77,000 die from the disease. Genetic testing of tumor tissue is required for most types of cancer to help make a diagnosis and to choose treatments. New methods are now being developed that can test blood to detect genetic changes in the tumor. Blood tests would avoid surgery, may be cheaper and might be useful for following the size of a patient's tumor. The aim of this project is to create an automated single genetic test that will be able to detect many cancer genetic changes at once, and can be used either on the tumor tissue or on blood. The test will be used to help make a diagnosis, and also possibly to monitor whether a patient is responding to treatment, or whether the cancer has returned. We will work with physicians at the BC Cancer Agency to make the reporting of the test results quick and convenient, and determine how this new test would change the management of cancer patients. We expect the test will be used in several provinces and research groups through our clinical testing laboratory, and help improve the management of cancer patients.
Department
Program
Collaborative Health Research Projects (NSERC partnered)
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
336921
Name
Karsan Aly
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Partnername
Natural Sciences and Engineering Research Council of Canada (NSERC)
Instname2
Cancer Research
Theme2
Clinical
Prcname2
Collaborative Health Research Projects - NSERC Partnered
Projecttitle
Development of an automated end-to-end next generation sequencing assay to detect all classes of genetic variant in a single diagnostic test
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$453,152
Cihrequipment2
$0
Programname2
Collaborative Health Research Projects (NSERC partnered)
Keyworddelim
1101 - Human Health; 5002- Molecular Genetics; 5004- Genome Analysis; 8000- Health Services; Analytical Validation; Bioinformatics; Clinical Cancer Genomics; Clinical Diagnostics; Clinical Utility; Next-Generation Sequencing
Abstract
Each year more than 190,000 Canadians are diagnosed with cancer and about 77,000 die from the disease. Genetic testing of tumor tissue is required for most types of cancer to help make a diagnosis and to choose treatments. New methods are now being developed that can test blood to detect genetic changes in the tumor. Blood tests would avoid surgery, may be cheaper and might be useful for following the size of a patient's tumor. The aim of this project is to create an automated single genetic test that will be able to detect many cancer genetic changes at once, and can be used either on the tumor tissue or on blood. The test will be used to help make a diagnosis, and also possibly to monitor whether a patient is responding to treatment, or whether the cancer has returned. We will work with physicians at the BC Cancer Agency to make the reporting of the test results quick and convenient, and determine how this new test would change the management of cancer patients. We expect the test will be used in several provinces and research groups through our clinical testing laboratory, and help improve the management of cancer patients.
Competitiondate
201510
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Karsan, Aly; Marra, Marco A
Approvedterm
3 ans 0 mois
Cihrcontribution2
Major Initiatives #2~ $453,152~ $0~
