Grant: Cat Gr: Develop./validation of new biomedical techniques/technolo.- General Pool

The ability to measure cell signals in intact tissue if a living organism is revolutionizing biomedical sciences. In particular, the advent of light-activated proteins, which can reveal virtually every signalling events inside cells, and also allow us to control these signals open an immense array of possibilities to understand disease process and even envisage novel therapeutic avenues. A key element in this endeavour is to develop the proper tools to deliver and collect light inside the living tissue. The current proposal aims to develop a novel type of miniaturised fiber optic that will enable monitoring and control of multiple cells, independently within tissue, with previously unachieved precision and speed.