Grant: Operating Grant - PA: Institute of Genetics (Bridge Funding)
University of Victoria (British Columbia)
$100,000.00
Role of global post-translational modifications, histone variants and linker histones in chromatin folding and function.
FY 2008-09
Summary
DNA is the repository molecule for genetic information. In multicellular organisms, like humans, the DNA strands are associated with specific proteins called histones. Portions of the DNA are wrapped around histones forming tight coils. The association between DNA and histones, called chromatin, helps to store the large amount of DNA within the limited space of the cell nucleus. This also helps to regulate the expression of genes. The way in which the different histones are precisely arranged onto the DNA is very important for chromatin function. Also, metabolic (chemical) modifications of histones such as acetylation and/or phosphorylation, play a critical role in fine-tuning the histone-DNA interactions which allow for the proper storage and expression of genes. Understanding the transitions undergone by chromatin as a result of these structural and metabolic changes is of utmost importance in order to ascertain the mechanisms involved in altered chromatin conformations which occur in many genetic diseases such as cancer.
Department
Program
Operating Grant - PA: Institute of Genetics (Bridge Funding)
Location
British Columbia, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
178858
Name
Ausio Juan
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Role of global post-translational modifications, histone variants and linker histones in chromatin folding and function.
Programtype2
Operating Grants
Orgnameinp2
University of Victoria (British Columbia)
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Operating Grant - PA: Institute of Genetics (Bridge Funding)
Keyworddelim
Analytical Ultracentrifuge; Chromatin; Chromatin Immunoprecipitation; Fluorescence Recovery After Photobleaching; Histones; Mass Spectrometry
Abstract
DNA is the repository molecule for genetic information. In multicellular organisms, like humans, the DNA strands are associated with specific proteins called histones. Portions of the DNA are wrapped around histones forming tight coils. The association between DNA and histones, called chromatin, helps to store the large amount of DNA within the limited space of the cell nucleus. This also helps to regulate the expression of genes. The way in which the different histones are precisely arranged onto the DNA is very important for chromatin function. Also, metabolic (chemical) modifications of histones such as acetylation and/or phosphorylation, play a critical role in fine-tuning the histone-DNA interactions which allow for the proper storage and expression of genes. Understanding the transitions undergone by chromatin as a result of these structural and metabolic changes is of utmost importance in order to ascertain the mechanisms involved in altered chromatin conformations which occur in many genetic diseases such as cancer.
Competitiondate
200809
Approvedterm2
1 yr 0 mth
Pinamesdelim
Ausio, Juan
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
