Grant: Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
University of Manitoba
$105,000.00
Age-related pathophysiological changes and targeted therapy in Chronic Lymphocytic Leukemia (CLL).
FY 2010-11
Summary
Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia. CLL is a disease of the elderly, and the survival rate falls with increasing age. We have identified potential factors that may explain this age-related phenomenon, and we are endeavouring to understand their mechanism of action. Another focus of my research project is characterizing new chemotherapy drugs that may be used to treat CLL. We are focusing on two drugs, Valproic Acid and Gefitinib, that are already in the clinics for treating other diseases. Combining these drugs with the conventional therapy should result in reduced side effects and improved survival. Current experiments are aimed at better understanding the actions of the two drugs on CLL cells.
Department
Program
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
229601
Name
Yoon Ju-Yoon
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Doctoral Research Awards - A
Projecttitle
Age-related pathophysiological changes and targeted therapy in Chronic Lymphocytic Leukemia (CLL).
Programtype2
Studentship Programs
Orgnameinp2
University of Manitoba
Cihramount2
$105,000
Cihrequipment2
$0
Programname2
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Keyworddelim
Aging; Chronic Lymphocytic Leukemia; Cytokine; Epidemiology; Gefitinib; Histone Deacetylase Inhibitors; Spleen Tyrosine Kinase; Translational Research; Valproic Acid
Abstract
Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia. CLL is a disease of the elderly, and the survival rate falls with increasing age. We have identified potential factors that may explain this age-related phenomenon, and we are endeavouring to understand their mechanism of action. Another focus of my research project is characterizing new chemotherapy drugs that may be used to treat CLL. We are focusing on two drugs, Valproic Acid and Gefitinib, that are already in the clinics for treating other diseases. Combining these drugs with the conventional therapy should result in reduced side effects and improved survival. Current experiments are aimed at better understanding the actions of the two drugs on CLL cells.
Competitiondate
201010
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Yoon, Ju-Yoon
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $105,000~ $0~
