Grant: CIHR Fellowship
Direct Payment
$150,000.00
R-loop and Transcriptional Profiles in Individual Hypothalamic Neurons following Augmented Maternal Care
FY 2015-16
Summary
Early life experience shapes an individual for a lifetime. While risk factors for mental health disorders are frequent in the population and intensely studied, much less is known about protective factors that allow for resilience in the face of adversity. Interestingly, enhanced maternal care in early life is associated with resilience to stress and improved learning and memory throughout life. Enhanced maternal care is capable of altering gene expression and the resulting epigenetic code in the hypothalamus of the brain. By studying a well established rodent model of enhanced maternal care with state-of-the-art technologies it will be possible to precisely map these protective epigenetic changes in individual neurons and begin to understand the molecular mechanisms behind them. Once identified, these changes can then be targeted by modern biotechnology and eventually be translated as a novel treatment for human mental health disorders.
Department
Program
CIHR Fellowship
Recipient
Location
California, United States of America
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
339330
Name
Laufer Benjamin
Region
California
Country
United States of America
Orgtype
Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
R-loop and Transcriptional Profiles in Individual Hypothalamic Neurons following Augmented Maternal Care
Programtype2
Fellowship Programs
Orgnameinp2
Direct Payment
Cihramount2
$150,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Augmented Maternal Care Rat Model; Bioinformatics; Dna-Rna Immunoprecipitation (Drip) Sequencing; Epigenomics; Individual Neuron; Mental Health; R-Loops; Resilience; Singe Cell Rna Sequencing; Stress
Abstract
Early life experience shapes an individual for a lifetime. While risk factors for mental health disorders are frequent in the population and intensely studied, much less is known about protective factors that allow for resilience in the face of adversity. Interestingly, enhanced maternal care in early life is associated with resilience to stress and improved learning and memory throughout life. Enhanced maternal care is capable of altering gene expression and the resulting epigenetic code in the hypothalamus of the brain. By studying a well established rodent model of enhanced maternal care with state-of-the-art technologies it will be possible to precisely map these protective epigenetic changes in individual neurons and begin to understand the molecular mechanisms behind them. Once identified, these changes can then be targeted by modern biotechnology and eventually be translated as a novel treatment for human mental health disorders.
Competitiondate
201511
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Laufer, Benjamin
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $150,000~ $0~
