Grant: Operating Grant
University of Toronto
$823,600.00
The role of mRNA processing bodies in genome stability
FY 2013-14
Summary
Before a cell can grow and divide it must duplicate its DNA. Mistakes during the copying of the DNA can lead to the kinds of changes that are frequently seen in cancerous cells. These changes are important for cancer development, progression, and treatment, but there is little information about how they arise. Understanding how they arise could lead to improvements in cancer detection and treatment. We will study how a protein that turns genes off prevents mistakes during the copying of the DNA.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
305686
Name
Brown Grant W
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
The role of mRNA processing bodies in genome stability
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$823,600
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Dna Damage; Dna Replication; Functional Genomics; Genome Instability; High Content Screening; Mrna Decay; Yeast Genetics
Abstract
Before a cell can grow and divide it must duplicate its DNA. Mistakes during the copying of the DNA can lead to the kinds of changes that are frequently seen in cancerous cells. These changes are important for cancer development, progression, and treatment, but there is little information about how they arise. Understanding how they arise could lead to improvements in cancer detection and treatment. We will study how a protein that turns genes off prevents mistakes during the copying of the DNA.
Competitiondate
201403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Brown, Grant W
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $823,600~ $0~
