Grant: Operating Grant
University of Victoria (British Columbia)
$826,290.00
Identifying the role of Fragile-X Mental Retardation Protein (FMRP) in hippocampal learning and memory processes.
FY 2012-13
Summary
Fragile-X Mental Retardation Protein (FMRP)is a protein that is expressed in neurons throughout the brain. When this
protein is absent, humans will develop the most common form of mental retardation, Fragile-X Syndrome. FMRP itself is interesting because it interacts with over 800 different proteins in the brain. Our work seeks to determine if disruptions in it's interactions with other synaptic proteins, particularly the n-methyl-D-aspartate (NMDA) receptor, play a role in causing the learning and memory deficits chracteristic of Fragile X Syndrome. We also seek to determine if reversing deficits in FMRP expression can rescue learning and memory performance.
Department
Program
Operating Grant
Location
British Columbia, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
265818
Name
Christie Brian R
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Behavioural Sciences - A: Neurobiological Basis of Behavioural Processes
Projecttitle
Identifying the role of Fragile-X Mental Retardation Protein (FMRP) in hippocampal learning and memory processes.
Programtype2
Operating Grants
Orgnameinp2
University of Victoria (British Columbia)
Cihramount2
$826,290
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Electron Microscopy; Electrophysiology; Fragile-X Syndrome; Hippocampus; Neuroanatomy; Nmda; Sex Differences; Synaptic Plasticity
Abstract
Fragile-X Mental Retardation Protein (FMRP)is a protein that is expressed in neurons throughout the brain. When this
protein is absent, humans will develop the most common form of mental retardation, Fragile-X Syndrome. FMRP itself is interesting because it interacts with over 800 different proteins in the brain. Our work seeks to determine if disruptions in it's interactions with other synaptic proteins, particularly the n-methyl-D-aspartate (NMDA) receptor, play a role in causing the learning and memory deficits chracteristic of Fragile X Syndrome. We also seek to determine if reversing deficits in FMRP expression can rescue learning and memory performance.
Competitiondate
201209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Christie, Brian R
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $826,290~ $0~
