Grant: Operating Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$472,640.00
Exome capture in severe early onset Essential Tremor families.
FY 2010-11
Summary
Essential Tremor (ET) is a chronic brain disease characterize by tremors occurring during volitional movement of the arm. As the disease advances, patients may also experience head tremor and difficulties with coordination, gait and balance. The disease is present in 4.0% of individuals aged over 40. ET is the most common cause of tremor in humans and is among the most common neurological disorders. Although the causes of ET are poorly understood, the disease is known to have a strong genetic component. However, none of the existing results have been replicated. We propose to sequence the entire coding region of the genome (known as the exome) of individuals with ET in order to identify genetic variations associated
with the disease. Identifying such genes will help understand the pathological mechanisms of ET and open new avenues for the development of a treatment.
Department
Program
Operating Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
224531
Name
Rouleau Guy A
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
Exome capture in severe early onset Essential Tremor families.
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$472,640
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Essential Tremors; Functional Validation; Gene Identification; Genetic Variations; Whole Exome Sequencing
Abstract
Essential Tremor (ET) is a chronic brain disease characterize by tremors occurring during volitional movement of the arm. As the disease advances, patients may also experience head tremor and difficulties with coordination, gait and balance. The disease is present in 4.0% of individuals aged over 40. ET is the most common cause of tremor in humans and is among the most common neurological disorders. Although the causes of ET are poorly understood, the disease is known to have a strong genetic component. However, none of the existing results have been replicated. We propose to sequence the entire coding region of the genome (known as the exome) of individuals with ET in order to identify genetic variations associated
with the disease. Identifying such genes will help understand the pathological mechanisms of ET and open new avenues for the development of a treatment.
Competitiondate
201103
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Rouleau, Guy A
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $472,640~ $0~
