Grant: CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer
Queen's University (Kingston, Ontario)
$62,500.00
Investigating the therapeutic potential of innate immune memory for the treatment of breast cancer diagnosed in the postpartum decade
FY 2022-23
Summary
Postpartum breast cancer (PPBC) is breast cancer diagnosed within 10 years of giving birth. Women diagnosed with PPBC are more
likely to die of metastasis when compared with similar-aged women with breast cancer who have never been pregnant. We think
that the changesto the immune system that normally occur during pregnancy to support growth of the baby can also cause breast
cancer cellsto metastasize if breast cancer arises within 10 years of giving birth. We will use mouse modelsto study how cells of the
immune system can be trained to improve the body’s ability to stop PPBC from growing and spreading. Ultimately, our goal isto
provide knowledge that may translate into the development of new immune therapiesto treat women with PPBC.
Department
Program
CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
488258
Name
Cotechini Tiziana
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Cancer Research Society Inc.; Cancer Research Society Inc.
Instname2
Cancer Research
Prcname2
Special Cases
Projecttitle
Investigating the therapeutic potential of innate immune memory for the treatment of breast cancer diagnosed in the postpartum decade
Programtype2
Operating Grants
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$62,500
Cihrequipment2
$0
Programname2
CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer
Keyworddelim
Immunotherapy; Tumour Progression And Metastasis
Abstract
Postpartum breast cancer (PPBC) is breast cancer diagnosed within 10 years of giving birth. Women diagnosed with PPBC are more
likely to die of metastasis when compared with similar-aged women with breast cancer who have never been pregnant. We think
that the changesto the immune system that normally occur during pregnancy to support growth of the baby can also cause breast
cancer cellsto metastasize if breast cancer arises within 10 years of giving birth. We will use mouse modelsto study how cells of the
immune system can be trained to improve the body’s ability to stop PPBC from growing and spreading. Ultimately, our goal isto
provide knowledge that may translate into the development of new immune therapiesto treat women with PPBC.
Competitiondate
202302
Approvedterm2
1 yr 0 mth
Pinamesdelim
Cotechini, Tiziana
Approvedterm
1 an 0 mois
Cihrcontribution2
ICR~ $62,500~ $0~
