Grant: Operating Grant
Research Institute of the McGill University Health Centre
$709,705.00
Identify New Genes for Recurrent Molar Pregnancies and Characterize mechanisms of mole formation
FY 2012-13
Summary
Hydatidiform mole (HM) is a human pregnancy with no embryo. The paradoxical nature of this condition has fascinated and puzzled scientists in all civilizations since the time of Hippocrates. In western countries, HM occurs once in every 600 pregnancies, but at higher incidences in developing and underdeveloped countries. Among women with one HM, 1-6% will develop a second mole and 10-25% will have a second reproductive wastage, mostly as a spontaneous abortion. Molar pregnancies are the most common trophoblastic tumours, usually benign, but may degenerate into malignant choriocarcinomas and lead to the death of the patients. My group initiated genetic research on familial recurrent HM, identified and characterized the functions of the first known gene, NLRP7, for this condition. Patients with this condition are now offered DNA testing and counselled for future pregnancies. The aim of this proposal is to complete the validation of two identified genes during the last funding period and elucidate their functions in order to provide help for more patients with this condition
Department
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
278372
Name
Slim Rima
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
Identify New Genes for Recurrent Molar Pregnancies and Characterize mechanisms of mole formation
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$709,705
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Aneuploidies; Exome Sequencing; Foetal Loss; Functional Studies; Immunofluorescence; Inflammation; Molar Pregnancies; Postzygotic Cleavage Abnormalities; Spontaneous Abortions; Stillbirth
Abstract
Hydatidiform mole (HM) is a human pregnancy with no embryo. The paradoxical nature of this condition has fascinated and puzzled scientists in all civilizations since the time of Hippocrates. In western countries, HM occurs once in every 600 pregnancies, but at higher incidences in developing and underdeveloped countries. Among women with one HM, 1-6% will develop a second mole and 10-25% will have a second reproductive wastage, mostly as a spontaneous abortion. Molar pregnancies are the most common trophoblastic tumours, usually benign, but may degenerate into malignant choriocarcinomas and lead to the death of the patients. My group initiated genetic research on familial recurrent HM, identified and characterized the functions of the first known gene, NLRP7, for this condition. Patients with this condition are now offered DNA testing and counselled for future pregnancies. The aim of this proposal is to complete the validation of two identified genes during the last funding period and elucidate their functions in order to provide help for more patients with this condition
Competitiondate
201303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Slim, Rima
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $709,705~ $0~
