Grant: Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Memorial University of Newfoundland
$296,661.00
Heteroclitic Stimulation and CD5 Modulation as Strategies to Expand Human Immunodeficiency Virus-specific CD8+ T cell Recognition Breadth
FY 2010-11
Summary
One of the biggest obstacles to developing an effective vaccine against human immunodfeficiency virus (HIV) is the tremendous diversity of the virus. This allows the virus to rapidly evade both antibody and T cell-mediated immune responses. The most common approach to addressing viral variablilty in vaccine development has been to focus on identifying conserved sequences or structures within virus variants. There may also be ways to alter the nature of the immune response so that more viral variants are recognized. This research project involves two methods of expanding the capacity of the immune response to recognize variants of HIV. One method focuses on using specialized antigens to recruit a greater variety of immune cells to fight the virus. The other method focuses on using a greater variety of antigens so that those cells that are recruited recognize more variants of HIV. Together, these two approaches have the potential to expand the breadth of immunity to cover more variants of HIV and thus, increase the effectiveness of HIV vaccines.
Department
Program
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Recipient
Location
Newfoundland and Labrador, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
215179
Name
Grant Michael D
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Heteroclitic Stimulation and CD5 Modulation as Strategies to Expand Human Immunodeficiency Virus-specific CD8+ T cell Recognition Breadth
Programtype2
Operating Grants
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$296,661
Cihrequipment2
$0
Programname2
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Keyworddelim
Cd5; Cd8; Heteroclitic; Hiv; Hla; Immunology; Peptide; T Cell
Abstract
One of the biggest obstacles to developing an effective vaccine against human immunodfeficiency virus (HIV) is the tremendous diversity of the virus. This allows the virus to rapidly evade both antibody and T cell-mediated immune responses. The most common approach to addressing viral variablilty in vaccine development has been to focus on identifying conserved sequences or structures within virus variants. There may also be ways to alter the nature of the immune response so that more viral variants are recognized. This research project involves two methods of expanding the capacity of the immune response to recognize variants of HIV. One method focuses on using specialized antigens to recruit a greater variety of immune cells to fight the virus. The other method focuses on using a greater variety of antigens so that those cells that are recruited recognize more variants of HIV. Together, these two approaches have the potential to expand the breadth of immunity to cover more variants of HIV and thus, increase the effectiveness of HIV vaccines.
Competitiondate
201009
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Grant, Michael D
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $296,661~ $0~
