Grant: CIHR Fellowship
University of Alberta
$135,000.00
Structural Studies on the Rhomboid Family of Membrane Proteins Involved in Human Disease
FY 2010-11
Summary
Many of the proteins that malfunction in human disease are associated with the outer surface of the cell. Although these proteins are among the most important players in disease, very little is known about their 3D structure. Using a technique called X-ray crystallography, we aim to determine the 3D structure of several of these proteins. We have determined the structure of one class pf proteins, and this structure has provided us with invaluable information regarding their function. We now propose to solve the structure of another set of membrane proteins who play a role in cancer and heart disease.
Department
Program
CIHR Fellowship
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
214469
Name
Brooks Cory L
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Structural Studies on the Rhomboid Family of Membrane Proteins Involved in Human Disease
Programtype2
Fellowship Programs
Orgnameinp2
University of Alberta
Cihramount2
$135,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Derlin; Endoplasmic Reticulum Associated Degradation; Membrane Proteins; Rhomboid Peptidases; X-Ray Crystallography
Abstract
Many of the proteins that malfunction in human disease are associated with the outer surface of the cell. Although these proteins are among the most important players in disease, very little is known about their 3D structure. Using a technique called X-ray crystallography, we aim to determine the 3D structure of several of these proteins. We have determined the structure of one class pf proteins, and this structure has provided us with invaluable information regarding their function. We now propose to solve the structure of another set of membrane proteins who play a role in cancer and heart disease.
Competitiondate
201010
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Brooks, Cory L
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $135,000~ $0~
