Grant: Team Grant: Bringing Biology to Cancer Prevention - Tech, Tools and Methods
Queen's University (Kingston, Ontario)
$1,988,650.00
Extracellular Vesicle-Derived Biomarkers for Early Leukaemia Detection and Monitoring Exercise-Based Risk Reduction
FY 2025-26
Summary
Leukaemia is a serious type of cancer of the blood. It is important to find ways to detect it earlier and develop better treatments. Our research team is working on a new way to detect leukaemia early by using tiny particles in your blood called extracellular vesicles (EVs). These particles carry important messages between cells in your body. We discovered that these EVs change when someone has leukaemia. By looking at these changes, we hope to create a simple test to detect leukemia sooner. We also want to learn how these EVs might help cancer grow by giving tumours extra energy. Another part of our research looks at how exercise may protect against cancer. Scientists know that staying active lowers the risk of getting cancer, but we are not sure why. We think exercise might increase the number of EVs with helpful proteins. By the end of this project, we hope to create a test to detect leukaemia early and better understand how EVs play a role in cancer. Studying how exercise affects EVs will also help us understand why being active can reduce your chances of developing leukemia.
Department
Program
Team Grant: Bringing Biology to Cancer Prevention - Tech, Tools and Methods
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
560809
Name
Abraham Sheela A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Team Grant: Bringing Biology to Cancer Prevention 2
Projecttitle
Extracellular Vesicle-Derived Biomarkers for Early Leukaemia Detection and Monitoring Exercise-Based Risk Reduction
Programtype2
Operating Grants
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$1,988,650
Cihrequipment2
$0
Programname2
Team Grant: Bringing Biology to Cancer Prevention - Tech, Tools and Methods
Keyworddelim
Exercise; Extracellular Vesicles; Leukaemia; Liquid Biomarkers; Mitochondria
Abstract
Leukaemia is a serious type of cancer of the blood. It is important to find ways to detect it earlier and develop better treatments. Our research team is working on a new way to detect leukaemia early by using tiny particles in your blood called extracellular vesicles (EVs). These particles carry important messages between cells in your body. We discovered that these EVs change when someone has leukaemia. By looking at these changes, we hope to create a simple test to detect leukemia sooner. We also want to learn how these EVs might help cancer grow by giving tumours extra energy. Another part of our research looks at how exercise may protect against cancer. Scientists know that staying active lowers the risk of getting cancer, but we are not sure why. We think exercise might increase the number of EVs with helpful proteins. By the end of this project, we hope to create a test to detect leukaemia early and better understand how EVs play a role in cancer. Studying how exercise affects EVs will also help us understand why being active can reduce your chances of developing leukemia.
Competitiondate
202506
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Abraham, Sheela A; Chan, Edmond Y; De Felice, Fernanda G; Koushik, Anita; McGlory, Christopher; Tyryshkin, Kathrin
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,988,650~ $0~