Grant: Project Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$665,550.00
Mechanisms leading to extracellular and intracellular accumulation of tau in Alzheimer's disease
FY 2017-18
Summary
Tau protein is believed to stabilize microtubules, the railways responsible for the transport of proteins within a neuron. During the course of Alzheimer's disease, tau protein detaches from microtubules, accumulates and aggregates in neurons. Accumulation and aggregation of tau is correlated to cognitive deficits in patients. This accumulation is caused by deficient mechanisms of tau clearance. In mouse models of Alzheimer's disease, increase of tau clearance was shown to be beneficial to neurons and to prevent neuronal cell death.The events leading to tau accumulation and aggregation remain unclear. Our ultimate goal is to elucidate these mechanisms. Our research will have direct impact on the elaboration of new therapeutic strategies to prevent the accumulation of tau and thereby to prevent and/or reverse the disease.
Department
Program
Project Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
370970
Name
Leclerc Nicole
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Aging
Theme2
Biomedical
Prcname2
Biological and Clinical Aspects of Aging
Projecttitle
Mechanisms leading to extracellular and intracellular accumulation of tau in Alzheimer's disease
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$665,550
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Aggregation; Alzheimer'S Disease; Bioid; Dendrites; Endosomes; Filamin A; Neuronal Cultures; Protein-Protein Interactions; Secretion; Tau Protein
Abstract
Tau protein is believed to stabilize microtubules, the railways responsible for the transport of proteins within a neuron. During the course of Alzheimer's disease, tau protein detaches from microtubules, accumulates and aggregates in neurons. Accumulation and aggregation of tau is correlated to cognitive deficits in patients. This accumulation is caused by deficient mechanisms of tau clearance. In mouse models of Alzheimer's disease, increase of tau clearance was shown to be beneficial to neurons and to prevent neuronal cell death.The events leading to tau accumulation and aggregation remain unclear. Our ultimate goal is to elucidate these mechanisms. Our research will have direct impact on the elaboration of new therapeutic strategies to prevent the accumulation of tau and thereby to prevent and/or reverse the disease.
Competitiondate
201709
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Leclerc, Nicole
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $665,550~ $0~
