Grant: Project Grant

Communication between cells are performed through so-called cell signalling pathway, which are important to control several developmental and maintenance aspects of animals. Dysregulation of cell signalling can be problematic and lead to diseases, including cancers. One of the signalling pathway involved in various cancer, including some leukemias, is the Notch signalling pathway. By using an original approach, we have identified new regulators, including a potential therapeutic target, which can be blocked by existing drugs. Here we will further investigate the possibility to use these drugs and block particular Notch mediated cancers, such as T-cell Lymphoblastic Leukemia (T-ALL).