Grant: Project Grant
Ottawa Hospital Research Institute
$100,000.00
Mechanisms of endothelial microparticle formation and signaling in diabetes
FY 2016-17
Summary
People with diabetes are far more likely to suffer a heart attack than nondiabetics. Diabetes causes changes to the blood vessels and this is believed to responsible for the increased risk of heart attacks and stroke. This project seeks to expand our understanding of how diabetes causes damage to the blood vessels.
Microparticles are tiny pieces of cells that are released from dying cells in the body. Recently it has been found that the levels of microparticles in the blood are increased significantly in diabetes. Increased microparticles can predict a risk of a heart attack or death due to heart problems. The goal of this project is to determine how microparticles are formed in diabetes and how they may cause damage to blood vessels. We anticipate that by understanding the proteins carried by microparticles and the signaling that microparticles activate in diabetes we will be able to develop new drug treatments that can be used to reduce risk of heart and kidney problems in diabetes.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
351867
Name
Burger Dylan E
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Mechanisms of endothelial microparticle formation and signaling in diabetes
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Biomarker; Cell Biology; Diabetes; Endothelial; Extracellular Vesicles; Inflammation; Microparticles; Reactive Oxygen Species; Vascular; Vessel Myography
Abstract
People with diabetes are far more likely to suffer a heart attack than nondiabetics. Diabetes causes changes to the blood vessels and this is believed to responsible for the increased risk of heart attacks and stroke. This project seeks to expand our understanding of how diabetes causes damage to the blood vessels.
Microparticles are tiny pieces of cells that are released from dying cells in the body. Recently it has been found that the levels of microparticles in the blood are increased significantly in diabetes. Increased microparticles can predict a risk of a heart attack or death due to heart problems. The goal of this project is to determine how microparticles are formed in diabetes and how they may cause damage to blood vessels. We anticipate that by understanding the proteins carried by microparticles and the signaling that microparticles activate in diabetes we will be able to develop new drug treatments that can be used to reduce risk of heart and kidney problems in diabetes.
Competitiondate
201604
Approvedterm2
1 yr 0 mth
Pinamesdelim
Burger, Dylan E
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
