Grant: Summer Program in Aging

Exercise is a modifiable risk factor for dementia. There are two main types of exercise training: aerobic training (aimed at improving cardiovascular health), and resistance training (aimed at improving muscle strength). Although exercise improves thinking abilities (cognitive function) and may contribute to preventing dementia, we don't know which type of exercise training is most beneficial for older adults' cognitive health, or how these benefits happen. Our study's main goal is to study and compare the effects of different types of exercise training programs (aerobic training, resistance training, and their combination) on cognitive function of older adults living with mild cognitive impairment. In addition, the study aims to understand how each exercise benefits cognitive function. Individuals with mild cognitive impairment are at risk for dementia. Thus, maintaining their cognitive function will prolong their ability to live independently and with quality. No study to date has compared the effect or aerobic exercise, resistance training, and combined training on cognitive function in older adults with mild cognitive impairment. 216 participants with mild cognitive impairment will be equally divided into four groups: aerobic exercise, resistance training, combination training, and balance training (as the control group). Participants will exercise 4x/week. Before and after the intervention, we will measure their cognitive function, brain structure, and blood markers of brain health. Our results will allow more precise and individualized exercise recommendations that benefit cognitive function, which will improve quality of life and functional independence of older adults living with mild cognitive impairment. We aim to personalize exercise prescription, as well as offer evidence for alternative exercise types for older adults who cannot engage in aerobic exercise.