Grant: Project Grant
University of Alberta
$760,680.00
The regulation of homologous recombination by RNF138
FY 2015-16
Summary
DNA double-strand breaks are breaks in individual chromosomes that can arise as a result of metabolism (breathing oxygen) and from environmental sources. These breaks are commonly repaired by one of two mechanisms termed non-homologous end joining and homologous recombination. These two types of repair differ in a very important way. Non homologous end joining connects two pieces of DNA and does not have mechanisms to preserve the integrity of the DNA sequence. Hence, this can cause rearrangements of genes and chromosomes and loss of genetic material--all of which can contribute to the development of cancer. Homologous recombination preserves the original sequence. As such, the choice of pathways is important. We have found that RNF138 plays a critical role in suppressing the error-prone pathway and promoting the error-free pathway.
Department
Program
Project Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
345070
Name
Ismail Ismail H
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
The regulation of homologous recombination by RNF138
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$760,680
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Ctip; Dna Double-Strand Breaks; Dna End Resection; Dna Repair; Dna Repair Foci; Genomic Instability; Mrn; Rnf138; Rpa; Ubiquitylation
Abstract
DNA double-strand breaks are breaks in individual chromosomes that can arise as a result of metabolism (breathing oxygen) and from environmental sources. These breaks are commonly repaired by one of two mechanisms termed non-homologous end joining and homologous recombination. These two types of repair differ in a very important way. Non homologous end joining connects two pieces of DNA and does not have mechanisms to preserve the integrity of the DNA sequence. Hence, this can cause rearrangements of genes and chromosomes and loss of genetic material--all of which can contribute to the development of cancer. Homologous recombination preserves the original sequence. As such, the choice of pathways is important. We have found that RNF138 plays a critical role in suppressing the error-prone pathway and promoting the error-free pathway.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ismail, Ismail H
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $760,680~ $0~
