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Grant: Project Grant

Unity Health Toronto

$1,874,251.00

Strategies for the management of Atrial Fibrillation in patiEnts receiving Dialysis 2 (SAFE-D2)

FY 2024-25

Summary
Atrial fibrillation (AF) is a common heart rhythm problem among dialysis patients, which increases their risk of having a stroke. Blood thinners, like apixaban, are often prescribed to prevent strokes in people with AF. This study aims to find out if apixaban can help prevent strokes in dialysis patients with AF compared to not using any blood thinners. In this study, we will look at two groups of dialysis patients with AF. One group will take apixaban, a widely used blood thinner, and the other group will not take any blood thinner. The main goal of the study is to see if taking apixaban helps prevent strokes compared to not using any blood thinners. We will follow the participants for two years, collecting data on strokes, bleeding, and other important outcomes. The results will help doctors make better treatment decisions for dialysis patients with AF, aiming to improve their quality of life and reduce the risks of both strokes and bleeding. Ultimately, this study will help provide more personalized care for this vulnerable group.
Program
Project Grant
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database

As published

Id
524988
Name
Harel Ziv
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Randomized Controlled Trials
Projecttitle
Strategies for the management of Atrial Fibrillation in patiEnts receiving Dialysis 2 (SAFE-D2)
Programtype2
Operating Grants
Orgnameinp2
Unity Health Toronto
Cihramount2
$1,874,251
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Apixaban; Atrial Fibrillation; End Stage Renal Disease; Hemodialysis
Abstract
Atrial fibrillation (AF) is a common heart rhythm problem among dialysis patients, which increases their risk of having a stroke. Blood thinners, like apixaban, are often prescribed to prevent strokes in people with AF. This study aims to find out if apixaban can help prevent strokes in dialysis patients with AF compared to not using any blood thinners. In this study, we will look at two groups of dialysis patients with AF. One group will take apixaban, a widely used blood thinner, and the other group will not take any blood thinner. The main goal of the study is to see if taking apixaban helps prevent strokes compared to not using any blood thinners. We will follow the participants for two years, collecting data on strokes, bleeding, and other important outcomes. The results will help doctors make better treatment decisions for dialysis patients with AF, aiming to improve their quality of life and reduce the risks of both strokes and bleeding. Ultimately, this study will help provide more personalized care for this vulnerable group.
Competitiondate
202503
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Harel, Ziv; Wald, Ron
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $1,874,251~ $0~
Unity Health Toronto - $1,874,251 Grant (2024-25) | Canada Spends