Grant: Project Grant
Research Institute of the McGill University Health Centre
$937,125.00
Detecting and preventing epigenetic defects and adverse health outcomes associated with assisted reproduction
FY 2023-24
Summary
Assisted reproductive technologies (ART) account for 1-6% of live births in high income countries. While most children conceived using ART are healthy, increases in birth defects and abnormal health outcomes have been reported. Such adverse outcomes associated with ART have been attributed to ART techniques and/or the underlying parental infertility. Alterations in epigenetic marking of DNA, DNA methylation, have been implicated as a mechanism underlying the adverse effects of ART on the next generation. Here, we will assess the role of folate supplements in preventing ART-associated adverse outcomes as well as how individual paternal factors associated with male infertility, and known to affect DNA methylation in sperm, can influence ART outcomes.
Department
Program
Project Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
489634
Name
Trasler Jacquetta M
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Clinical Investigation - A: Reproduction, Maternal, Child and Youth Health 2
Projecttitle
Detecting and preventing epigenetic defects and adverse health outcomes associated with assisted reproduction
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$937,125
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Assisted Reproduction; Birth Defects; Dna Methylation; Embryo; Epigenetics; Folate; Intergenerational; Male Infertility; Mthfr; Sperm
Abstract
Assisted reproductive technologies (ART) account for 1-6% of live births in high income countries. While most children conceived using ART are healthy, increases in birth defects and abnormal health outcomes have been reported. Such adverse outcomes associated with ART have been attributed to ART techniques and/or the underlying parental infertility. Alterations in epigenetic marking of DNA, DNA methylation, have been implicated as a mechanism underlying the adverse effects of ART on the next generation. Here, we will assess the role of folate supplements in preventing ART-associated adverse outcomes as well as how individual paternal factors associated with male infertility, and known to affect DNA methylation in sperm, can influence ART outcomes.
Competitiondate
202309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Trasler, Jacquetta M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $937,125~ $0~
