Grant: Operating Grant
Université de Montréal
$1,076,250.00
Functional genomics to identify stem cell fate determinants
FY 2009-10
Summary
Stem cells have received considerable public attention in part because of their potential application in regenerative therapies. Stem cells can be operationally defined as cells that have the unique property to self-renew as well as to generate more differentiated progeny (differentiation). However, much remains to be learned about the genes regulating stem cell differentiation and renewal, their relationship to each other, and the signalling pathways that control their expression and/or activity. In this application, we propose to use a new resource developed in our laboratory in the last 6 years -called DelES, for chromosomal Deletion in ES cells, see www.bioinfo.iric.ca/deles- to efficiently identify novel genes and other elements which are essential for stem cell activity.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
189705
Name
Sauvageau Guy
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Functional genomics to identify stem cell fate determinants
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$1,076,250
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Bac Complementation; Chimeric Mouse; Chromosome Engineering; Comparative Genomic Hybridization Array; Es Cells; In Vitro Differentiation
Abstract
Stem cells have received considerable public attention in part because of their potential application in regenerative therapies. Stem cells can be operationally defined as cells that have the unique property to self-renew as well as to generate more differentiated progeny (differentiation). However, much remains to be learned about the genes regulating stem cell differentiation and renewal, their relationship to each other, and the signalling pathways that control their expression and/or activity. In this application, we propose to use a new resource developed in our laboratory in the last 6 years -called DelES, for chromosomal Deletion in ES cells, see www.bioinfo.iric.ca/deles- to efficiently identify novel genes and other elements which are essential for stem cell activity.
Competitiondate
200909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sauvageau, Guy
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,076,250~ $0~
