Grant: Project Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$577,575.00
Impact of vascular injury derived exosomes on Lupus Nephritis
FY 2021-22
Summary
Lupus nephritis is a type of kidney disease caused by systemic lupus erythematosus (SLE or lupus). Lupus is an autoimmune disease in which the body's immune system attacks the body's own cells and organs. Lupus nephritis (LN) is a serious manifestation, affecting 60% of adults and 80% of children with (SLE); about 30% of patients progress to kidney failure. During LN, it is known that the immune system attacks the small blood vessels but information the molecular mechanisms implicated in this attack and its impact has been very limited to date. Additionally, there remains an important unmet need for markers of LN disease activity and response to therapy. Our goal is to characterize the pathways that control small vessel damage in lupus models and patients to identify novel mechanisms and predictors of nephritis. This work has the potential to identify new therapeutic targets and to significantly improve the management of the kidney disease and outcomes for lupus patients.
Department
Program
Project Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
450725
Name
Dieudé Mélanie
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Clinical Investigation - B 2
Projecttitle
Impact of vascular injury derived exosomes on Lupus Nephritis
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$577,575
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Antibodies; Autoimmunity; Exosomes; Lupus Nephritis; Vascular Injury
Abstract
Lupus nephritis is a type of kidney disease caused by systemic lupus erythematosus (SLE or lupus). Lupus is an autoimmune disease in which the body's immune system attacks the body's own cells and organs. Lupus nephritis (LN) is a serious manifestation, affecting 60% of adults and 80% of children with (SLE); about 30% of patients progress to kidney failure. During LN, it is known that the immune system attacks the small blood vessels but information the molecular mechanisms implicated in this attack and its impact has been very limited to date. Additionally, there remains an important unmet need for markers of LN disease activity and response to therapy. Our goal is to characterize the pathways that control small vessel damage in lupus models and patients to identify novel mechanisms and predictors of nephritis. This work has the potential to identify new therapeutic targets and to significantly improve the management of the kidney disease and outcomes for lupus patients.
Competitiondate
202109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Dieudé, Mélanie
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $577,575~ $0~
