Grant: Operating Grant - PA: Institute of Genetics (Bridge Funding)

Cushing disease is caused by small pituitary tumors that lead to excessive production of adrenal glucocorticoids. The excessive levels of these steroids lead to severe metabolic imbalance and may result in diabetes, hypertension and/or osteoporosis. The hallmark of pituitary tumor cells that cause Cushing disease is that these cells are resistant to a hormone feedback mechanism that would normally restrict their growth. By investigating the mechanism of this negative feedback, we have identified proteins and mechanisms that explain hormone resistance. This research project will determine the link between hormone resistance and tumor formation. In addition, genes that are directly implicated in the process of tumorigenesis will be identified. The elucidation of molecular mechanisms underlying tumor formation is the most rationale way to develop novel therapies for cancer management.