Grant: Canada Research Chairs
University of Manitoba
$200,000.00
Structural Biology and Biophysics
FY 2024-25
Summary
A molecular understanding of the structure-property relationships of extracellular proteins involved in (i) the formation of dynamic high-order signaling complexes related to human disease and (ii) the establishment of unique S-layer assemblies from extremophilic archea is essential for the development of structure-based applications in the fields of biomedicine and biotechnology. The exploration of structural dynamics of proteins in cellular communication and cell-matrix signaling are of great biomedical importance. In a second avenue of research, we are exploiting S-layer coiled coils and eDNA to design non-invasive monitoring and remediation tools. The development of structure-guided applications based on the unique features of coiled coil nanotubes is a new approach in application-driven research. We will continue to apply and further develop an integrated research program combining high-resolution structural biology techniques, with various biophysical and functional approaches. The overarching goal is to continue to develop structure-based applications in the fields of biomedicine and biotechnology.
Program
Canada Research Chairs
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
CRC-2023-00164
Name nom
Stetefeld, Jörg
Department département
Chemistry and Microbiology - University of Manitoba
Organization id
19
Institution établissement
University of Manitoba
Province en
Manitoba
Province fr
Manitoba
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2024
Competition year année de concours
2023
Award amount
200000
Program id
CRC
Program name en
Canada Research Chairs
Program name fr
Chaires de recherche du Canada
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
9998
Committee name en
Canada Research Chair Selection Committee
Committee name fr
Comité de sélection des Chaires de recherche du Canada
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
9999
Research subject group en
Not available
Research subject group fr
Non disponible
Research subject en
Not available
Research subject fr
Non disponible
Field of research list codes
RDF1060207
Field of research list names en
Structural biology (including macromolecular modelling)
Field of research list names fr
Biologie structurale (y compris la modélisation macromoléculaire)
Socioeconomic objective list codes
RDS10701
Socioeconomic objective list names en
Human health procedures and pharmaceutical treatments
Socioeconomic objective list names fr
Interventions et traitements pharmaceutiques ayant trait à la santé humaine
Application title
Structural Biology and Biophysics
Keywords
Structural Biology; Biophysics; Hybrid Method Approach; Extracellular signalling complexes; Protein-Protein Networks; Structure-based Drug Design; Netrin-Dependence receptor hubs; CCN; non-invasive Biomonitoring tools; S-layer proteins
Application summary
A molecular understanding of the structure-property relationships of extracellular proteins involved in (i) the formation of dynamic high-order signaling complexes related to human disease and (ii) the establishment of unique S-layer assemblies from extremophilic archea is essential for the development of structure-based applications in the fields of biomedicine and biotechnology. The exploration of structural dynamics of proteins in cellular communication and cell-matrix signaling are of great biomedical importance. In a second avenue of research, we are exploiting S-layer coiled coils and eDNA to design non-invasive monitoring and remediation tools. The development of structure-guided applications based on the unique features of coiled coil nanotubes is a new approach in application-driven research. We will continue to apply and further develop an integrated research program combining high-resolution structural biology techniques, with various biophysical and functional approaches. The overarching goal is to continue to develop structure-based applications in the fields of biomedicine and biotechnology.
