Grant: Travel Awards - Institute Community Support
Université de Sherbrooke
$1,000.00
Neuroplasticity changes in rat brain following targeted irradiation assessed by diffusion MRI tractography validated by histology and behavioral tests
FY 2015-16
Summary
During stereotactic radiosurgery (SRS) for brain cancer, surrounding normal tissue may receive a significant radiation dose. This can frequently lead to brain swelling, necrosis, and neuronal dysfunction, thus inducing delayed side effects such as cognitive decline and stroke-like symptoms. We developed a radionecrosis animal-model to monitor brain tissue responses following SRS, by identifying unusual neuronal changes using different magnetic resonance imaging (MRI) modalities. Using appropriate MRI modalities, our results revealed that SRS treatment induces regional structural and functional changes, as demonstrated by neurovascular matrix remodeling and changes in behavioral responses. This project aims to demonstrate the need of advanced diagnostic/imaging tools to better predict adverse SRS event, and therefore develop new management strategies for clinicians.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
342474
Name
Constanzo Julie
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Institute of Cancer Research
Projecttitle
Neuroplasticity changes in rat brain following targeted irradiation assessed by diffusion MRI tractography validated by histology and behavioral tests
Programtype2
Undefined
Orgnameinp2
Université de Sherbrooke
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Behavior; Brain; Cognitive Decline; Gamma Knife; Histopathology; Magnetic Resonance Imaging; Neuronal Changes; Plasticity; Radiation Therapy; Stereotactic Radiosurgery
Abstract
During stereotactic radiosurgery (SRS) for brain cancer, surrounding normal tissue may receive a significant radiation dose. This can frequently lead to brain swelling, necrosis, and neuronal dysfunction, thus inducing delayed side effects such as cognitive decline and stroke-like symptoms. We developed a radionecrosis animal-model to monitor brain tissue responses following SRS, by identifying unusual neuronal changes using different magnetic resonance imaging (MRI) modalities. Using appropriate MRI modalities, our results revealed that SRS treatment induces regional structural and functional changes, as demonstrated by neurovascular matrix remodeling and changes in behavioral responses. This project aims to demonstrate the need of advanced diagnostic/imaging tools to better predict adverse SRS event, and therefore develop new management strategies for clinicians.
Competitiondate
201601
Approvedterm2
1 yr 0 mth
Pinamesdelim
Constanzo, Julie
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Cancer Research~ $1,000~ $0~
