Grant: Project Grant - Priority Announcement - Cancer Survivorship
Sunnybrook Research Institute (Toronto, Ontario)
$100,000.00
Stereotactic Radiotherapy for Spinal Metastases: Quantifying the Impact on Musculoskeletal Health
FY 2023-24
Summary
Focused high dose (stereotactic body) radiation therapy (SBRT) has shown excellent results in the treatment of cancer that has spread (metastasized) to the bones of the spine. However, as patients are living longer following SBRT, it is critical to understand the impact of this treatment on their bone and muscle health. This research aims to use a vast dataset of existing medical imaging (CT and MRI scans) to evaluate the impact of SBRT on osteosarcopenia (the loss of both bone and muscle) and spinal alignment over time in patients with spinal metastases. Further, this study will prospectively follow patients following SBRT with imaging-based measurements (using an automated pipeline) and determine their relationship to pain, function, strength and quality of life measured over a 3 year follow up. Improving understanding of the incidence and progression of osteosarcopenia and spinal deformity following SBRT will allow us to better identify patients at high risk of musculoskeletal decline and tailor treatment delivery to both destroy spine tumors and preserve bone and muscle health.
Department
Program
Project Grant - Priority Announcement - Cancer Survivorship
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
503832
Name
Whyne Cari M
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Clinical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Stereotactic Radiotherapy for Spinal Metastases: Quantifying the Impact on Musculoskeletal Health
Programtype2
Operating Grants
Orgnameinp2
Sunnybrook Research Institute (Toronto, Ontario)
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Project Grant - Priority Announcement - Cancer Survivorship
Keyworddelim
Ambispective Cohort; Ct And Mri; Imaging Biomarkers; Machine Learning; Musculoskeletal Health; Osteosarcopenia; Pain, Function And Strength Measurements; Spinal Deformity; Spinal Metastases; Stereotactic Body Radiotherapy
Abstract
Focused high dose (stereotactic body) radiation therapy (SBRT) has shown excellent results in the treatment of cancer that has spread (metastasized) to the bones of the spine. However, as patients are living longer following SBRT, it is critical to understand the impact of this treatment on their bone and muscle health. This research aims to use a vast dataset of existing medical imaging (CT and MRI scans) to evaluate the impact of SBRT on osteosarcopenia (the loss of both bone and muscle) and spinal alignment over time in patients with spinal metastases. Further, this study will prospectively follow patients following SBRT with imaging-based measurements (using an automated pipeline) and determine their relationship to pain, function, strength and quality of life measured over a 3 year follow up. Improving understanding of the incidence and progression of osteosarcopenia and spinal deformity following SBRT will allow us to better identify patients at high risk of musculoskeletal decline and tailor treatment delivery to both destroy spine tumors and preserve bone and muscle health.
Competitiondate
202403
Approvedterm2
1 yr 0 mth
Pinamesdelim
Whyne, Cari M; Hardisty, Michael R; Sahgal, Arjun
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
