Grant: Project Grant
Queen's University (Kingston, Ontario)
$956,250.00
Investigating the PTK-Hippo axis in breast cancer metastasis
FY 2022-23
Summary
Breast cancer is the most frequently diagnosed cancer in women, killing about 680,000 people worldwide each year. Of all these women, over 90% of them die of tumor metastasis, a process in which tumors spread from the breast to other parts of the body such as lung and bone. However, treatment for metastatic breast cancer is not effective because we do not fully understand how cancer cells spread. In this research project, we will explore how a group of genes called "Hippo" and its partners work together to control breast cancer spreading. We will also test whether inhibiting them can stop breast cancer metastasis. Our studies studies will inform the design of new treatment strategies aimed at blocking the metastatic spread of breast cancer in the future.
Department
Program
Project Grant
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
468075
Name
Yang Xiaolong
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics 2
Projecttitle
Investigating the PTK-Hippo axis in breast cancer metastasis
Programtype2
Operating Grants
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$956,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Breast Cancer; Cell Migration And Invasion; Combination Therapy; Hippo Pathway; Kinases; Metastasis; Protein Tyrosine Kinases; Signal Transduction; Targeted Therapy; Xenograft Mouse Model
Abstract
Breast cancer is the most frequently diagnosed cancer in women, killing about 680,000 people worldwide each year. Of all these women, over 90% of them die of tumor metastasis, a process in which tumors spread from the breast to other parts of the body such as lung and bone. However, treatment for metastatic breast cancer is not effective because we do not fully understand how cancer cells spread. In this research project, we will explore how a group of genes called "Hippo" and its partners work together to control breast cancer spreading. We will also test whether inhibiting them can stop breast cancer metastasis. Our studies studies will inform the design of new treatment strategies aimed at blocking the metastatic spread of breast cancer in the future.
Competitiondate
202209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Yang, Xiaolong
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $956,250~ $0~
