Grant: Operating Grant
University of British Columbia
$586,484.00
Pathogen adaptation and AIDS-associated Cryptococcosis
FY 2008-09
Summary
This project focuses on understanding the ways in which deadly fungal pathogens attack people with weakened immune systems. In particular, the project will study the fungal pathogen Cryptococcus neoformans. This pathogen is the most common cause of life-threatening brain infections in people with acquired immune deficiency syndrome (AIDS). The project will test whether an animal model of AIDS is useful for studying ways to treat infections caused by Cryptococcus neoformans. In addition, possible new targets for drug therapies will be examined.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
170781
Name
Kronstad James W
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Microbiology & Infectious Diseases
Projecttitle
Pathogen adaptation and AIDS-associated Cryptococcosis
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$586,484
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Animal Model; Fungal Disease; Gene Deletion; Microarrays; Transcription
Abstract
This project focuses on understanding the ways in which deadly fungal pathogens attack people with weakened immune systems. In particular, the project will study the fungal pathogen Cryptococcus neoformans. This pathogen is the most common cause of life-threatening brain infections in people with acquired immune deficiency syndrome (AIDS). The project will test whether an animal model of AIDS is useful for studying ways to treat infections caused by Cryptococcus neoformans. In addition, possible new targets for drug therapies will be examined.
Competitiondate
200809
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Kronstad, James W
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $586,484~ $0~
