Grant: CIHR Fellowship
University of British Columbia
$135,000.00
Advancing understanding of voltage-gated calcium channel regulation by STAC proteins using cryo-EM
FY 2018-19
Summary
Skeletal and heart muscle contraction requires calcium ions. Calcium ions enter muscle cells through "calcium channels", which are effectively gates made up of protein. The exact timing of the opening and closing of these gates is critical to the proper function of muscle. Any deviation can cause calcium excess, which may result in disease. These include inherited cardiac arrhythmias or muscular disorders (e.g. Native American myopathy). This project aims to uncover how other proteins can interact with these gates and promote their opening and how they might contribute to diseases of dysregulation.
Department
Program
CIHR Fellowship
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
396418
Name
Gagnon Susannah M
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Advancing understanding of voltage-gated calcium channel regulation by STAC proteins using cryo-EM
Programtype2
Fellowship Programs
Orgnameinp2
University of British Columbia
Cihramount2
$135,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Biochemistry; Biophysics; Cryo-Electron Microscopy; Electrophysiology; Ion Channels; Mechanism; Membrane Proteins; Muscle Regulation; Structural Biology
Abstract
Skeletal and heart muscle contraction requires calcium ions. Calcium ions enter muscle cells through "calcium channels", which are effectively gates made up of protein. The exact timing of the opening and closing of these gates is critical to the proper function of muscle. Any deviation can cause calcium excess, which may result in disease. These include inherited cardiac arrhythmias or muscular disorders (e.g. Native American myopathy). This project aims to uncover how other proteins can interact with these gates and promote their opening and how they might contribute to diseases of dysregulation.
Competitiondate
201811
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Gagnon, Susannah M
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $135,000~ $0~
