Grant: Project Grant
University of Toronto
$887,400.00
A general strategy to develop inhibitors for transcription factors
FY 2017-18
Summary
Most current drugs focus only on a few established target proteins. Transcription factors are both one of the largest and one of the most important groups of proteins in humans. For instance, a large fraction of cancers are caused by aberrations in transcription factors. However, to date no drug that targets them has been developed. We are here proposing a novel integrated strategy to develop inhibitors to transcription factors that would potentially establish a whole new class of drugs.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
380690
Name
Kim Philip M
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genomics: Systems and computational biology
Projecttitle
A general strategy to develop inhibitors for transcription factors
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$887,400
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bacterial-One-Hybrid; Drug Discovery; Protein Design; Transcription Factor; Yeast-Two-Hybrid
Abstract
Most current drugs focus only on a few established target proteins. Transcription factors are both one of the largest and one of the most important groups of proteins in humans. For instance, a large fraction of cancers are caused by aberrations in transcription factors. However, to date no drug that targets them has been developed. We are here proposing a novel integrated strategy to develop inhibitors to transcription factors that would potentially establish a whole new class of drugs.
Competitiondate
201803
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Kim, Philip M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $887,400~ $0~
