Grant: Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
University of Manitoba
$395,586.00
Regulation of IRF-1 in Immune Activation and HIV Infection
FY 2009-10
Summary
Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) continues to be the most devastating infectious disease in modern history, with over 60 million individuals infected or dead since 1980. The development of a vaccine against HIV is the best hope to stop this epidemic. Current vaccine research is at a standstill due to a lack of knowledge of what might protect against HIV infection. A group of women, who are highly exposed to HIV, but dont get infected may provide an answer. These women may produce a smaller amount of a human gene known as IRF-1 which has been shown to help HIV replicate, and is important in generating immune responses in humans. This gene has not been studied closely in living humans. The studies proposed here will determine if the IRF-1 gene is important in protecting people against HIV infection and development of AIDS.
Department
Program
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
197694
Name
Ball Terry B
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Regulation of IRF-1 in Immune Activation and HIV Infection
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$395,586
Cihrequipment2
$0
Programname2
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Keyworddelim
Hiv; Hiv Replication; Hiv Resistance; Immune Activation; Irf-1; Signalling
Abstract
Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) continues to be the most devastating infectious disease in modern history, with over 60 million individuals infected or dead since 1980. The development of a vaccine against HIV is the best hope to stop this epidemic. Current vaccine research is at a standstill due to a lack of knowledge of what might protect against HIV infection. A group of women, who are highly exposed to HIV, but dont get infected may provide an answer. These women may produce a smaller amount of a human gene known as IRF-1 which has been shown to help HIV replicate, and is important in generating immune responses in humans. This gene has not been studied closely in living humans. The studies proposed here will determine if the IRF-1 gene is important in protecting people against HIV infection and development of AIDS.
Competitiondate
200909
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Ball, Terry B
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $395,586~ $0~
