Grant: Travel Awards - Institute Community Support
Direct Payment
$1,100.00
Memory B cells and active antibody production are present in ectopic lymphoid structures in the epicardial coronary arteries of cardiac transplant patients
FY 2013-14
Summary
The first-line option for patients with heart failure is a transplant. Although newer drugs have improved the early survival of patients, rates of long-term survival after a transplant have not improved. This is because of a large lesion that develops in the arteries of the transplant, and this lesion develops from the patient's immune system reacting to the transplanted heart. This lesion can cause a blockage in the arteries and prevent blood flow to and from the heart. When looking at arteries from patients with a heart transplant, we see organized groups of immune cells near the damaged arteries. Our research is trying to determine what these types of cells are and how we can stop them from causing the lesion to develop in the transplanted heart.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
Nova Scotia, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
304066
Name
Gareau Alison
Region
Nova Scotia
Country
Canada
Orgtype
Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Institute of Circulatory and Respiratory Health
Projecttitle
Memory B cells and active antibody production are present in ectopic lymphoid structures in the epicardial coronary arteries of cardiac transplant patients
Programtype2
Undefined
Orgnameinp2
Direct Payment
Cihramount2
$1,100
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Ics Travel Awards
Abstract
The first-line option for patients with heart failure is a transplant. Although newer drugs have improved the early survival of patients, rates of long-term survival after a transplant have not improved. This is because of a large lesion that develops in the arteries of the transplant, and this lesion develops from the patient's immune system reacting to the transplanted heart. This lesion can cause a blockage in the arteries and prevent blood flow to and from the heart. When looking at arteries from patients with a heart transplant, we see organized groups of immune cells near the damaged arteries. Our research is trying to determine what these types of cells are and how we can stop them from causing the lesion to develop in the transplanted heart.
Competitiondate
201401
Approvedterm2
0 yr 3 mths
Pinamesdelim
Gareau, Alison
Approvedterm
0 an 3 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $1,100~ $0~
