Grant: Strategic Projects Supplemental Competition

This strategic research is to develop a high-performance early warning monitoring systems for water resources so that citizens can receive early warning if hazardous events occur. The technology to be developed will have a great potential to gain a critical time lead for detection of disastrous events in water resources so that measures can be taken to reduce or eliminate dangerous consequences.  A real-time cell electronic sensor (RT-CES) array has recently been proven valuable for continuously monitoring dynamic cytotoxicity responses of living cells. With RT-CES technology, we have established apreliminary framework for dynamic cytotoxicity modeling by applying dynamic systems modeling theory and this dynamic model has shown a great potential in modeling cell dynamics in the presence of toxicant and, more importantly, predicting the cytotoxicity response of the cells. The success of our preliminary study leads to this proposal.  We expect that this monitoring system has a great potential to be more reliable, more accurate, more environmentally and ecologically friendly, and faster than other conventional methods. The key technology to be used includes dynamic RT-CES monitoring system, rigorous mathematical modeling, dynamic predictions, and direct testing of the toxicant effect on living cells.