Grant: Project Grant - PA: Infection and Immunity (Early Career Research Support)
Ottawa Hospital Research Institute
$300,000.00
When the Killers become Thieves: NK cells are suppressed by trogocytosed PD-1.
FY 2021-22
Summary
Natural Killer cells are lymphocytes with a known anti-cancer activity. Our lab is interested in understanding how cancer suppress Natural Killer cells and to find new ways to potentiate the response of Natural Killer cells against tumors. We recently discovered that Natural Killer cells acquire parts of the membrane of cancer cells, in a process known as trogocytosis. While performing trogocytosis, Natural Killer cells acquire inhibitory molecules, such as PD-1, which suppress their activation. Here, we propose to study the mechanisms underlying PD-1 acquisition on Natural Killer cells and to define the functional consequences of trogocytosed PD-1 on Natural Killer cells. Results from this research will shed light on a new immune-regulatory mechanism and will provide new targets for cancer immunotherapy.
Department
Program
Project Grant - PA: Infection and Immunity (Early Career Research Support)
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
447611
Name
Ardolino Michele
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
When the Killers become Thieves: NK cells are suppressed by trogocytosed PD-1.
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$300,000
Cihrequipment2
$0
Programname2
Project Grant - PA: Infection and Immunity (Early Career Research Support)
Keyworddelim
Cancer Immunotherapy; Checkpoint Blockade; Innate Immunity; Multiple Myeloma; Nk Cells; Pd-1; Pd-L1; Slam Receptors; Trogocytosis; Tumor Immunology
Abstract
Natural Killer cells are lymphocytes with a known anti-cancer activity. Our lab is interested in understanding how cancer suppress Natural Killer cells and to find new ways to potentiate the response of Natural Killer cells against tumors. We recently discovered that Natural Killer cells acquire parts of the membrane of cancer cells, in a process known as trogocytosis. While performing trogocytosis, Natural Killer cells acquire inhibitory molecules, such as PD-1, which suppress their activation. Here, we propose to study the mechanisms underlying PD-1 acquisition on Natural Killer cells and to define the functional consequences of trogocytosed PD-1 on Natural Killer cells. Results from this research will shed light on a new immune-regulatory mechanism and will provide new targets for cancer immunotherapy.
Competitiondate
202104
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Ardolino, Michele
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $300,000~ $0~
