Grant: Travel Awards - Institute Community Support
University of Manitoba
$1,000.00
To improve chemotherapeutic responses in CNS malignancy through suppression of hyperactive DNA damage repair pathways
FY 2016-17
Summary
The quality of life of patients who suffer from malignant medulloblastoma and prognoses of glioblastoma multiforme remains abysmal. Conventional chemotherapeutics have limited success due to over-activity of DNA repair pathways which counteract therapeutic DNA damage. DNA repair pathways induce a diverse variety of coordinately-acting proteins and enzymes, which can be differentially expressed in tumor cells in response to DNA damage. My goal is to inhibit highly active enzymes, determine their therapeutic-countering mechanistic function and to develop a combination therapy that will ameliorate sensitization of tumor cells and hence develop more effective and successful anti-brain cancer therapeutic regimens.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
352431
Name
Mostafizar Marina
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Institute of Cancer Research
Projecttitle
To improve chemotherapeutic responses in CNS malignancy through suppression of hyperactive DNA damage repair pathways
Programtype2
Undefined
Orgnameinp2
University of Manitoba
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Ics Travel Awards
Abstract
The quality of life of patients who suffer from malignant medulloblastoma and prognoses of glioblastoma multiforme remains abysmal. Conventional chemotherapeutics have limited success due to over-activity of DNA repair pathways which counteract therapeutic DNA damage. DNA repair pathways induce a diverse variety of coordinately-acting proteins and enzymes, which can be differentially expressed in tumor cells in response to DNA damage. My goal is to inhibit highly active enzymes, determine their therapeutic-countering mechanistic function and to develop a combination therapy that will ameliorate sensitization of tumor cells and hence develop more effective and successful anti-brain cancer therapeutic regimens.
Competitiondate
201607
Approvedterm2
1 yr 0 mth
Pinamesdelim
Mostafizar, Marina
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Cancer Research~ $1,000~ $0~
