Grant: Catalyst Grant: Pandemic Preparedness
Memorial University of Newfoundland
$98,131.00
In vivo treatment of influenza virus infection with a MEK inhibitor
FY 2009-10
Summary
Virus infection is recognized as a current growing problem which causes damages in public health and societies. Despite very successful vaccinations against some viruses in the past, there are not many anti-viral drugs available for ongoing infection. Basic research on cellular microenvironments that support efficient viral replication will lead us to the possible development of a new anti-viral drug. In the proposed study, we will focus on a cellular signaling pathway, called Ras/MEK/ERK, whose activation promotes influenza virus infection and reduces cellular resistance to the infection. We will investigate whether it is possible to use a chemical inhibitor against Ras/MEK/ERK activation in treatment of mice infected with influenza virus.
Department
Program
Catalyst Grant: Pandemic Preparedness
Recipient
Location
Newfoundland and Labrador, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
183182
Name
Hirasawa Kensuke
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Pandemic Preparedness
Projecttitle
In vivo treatment of influenza virus infection with a MEK inhibitor
Programtype2
Operating Grants
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$98,131
Cihrequipment2
$0
Programname2
Catalyst Grant: Pandemic Preparedness
Keyworddelim
Infection; Influenza Virus; Innate Immunity; Ras/Mek/Erk Pathway
Abstract
Virus infection is recognized as a current growing problem which causes damages in public health and societies. Despite very successful vaccinations against some viruses in the past, there are not many anti-viral drugs available for ongoing infection. Basic research on cellular microenvironments that support efficient viral replication will lead us to the possible development of a new anti-viral drug. In the proposed study, we will focus on a cellular signaling pathway, called Ras/MEK/ERK, whose activation promotes influenza virus infection and reduces cellular resistance to the infection. We will investigate whether it is possible to use a chemical inhibitor against Ras/MEK/ERK activation in treatment of mice infected with influenza virus.
Competitiondate
200904
Approvedterm2
1 yr 0 mth
Pinamesdelim
Hirasawa, Kensuke
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $98,131~ $0~
